1. The common side effect in intravenous melphalan is mucositis.

2. Melphalan ( L - PAM ) is approved by FDA for marketing.

3. This phase 3 study compared the use of melphalan and prednisone with or without bortezomib in previously untreated patients with multiple myeloma who were ineligible for high-dose therapy.

4. Try to avoid using Phenylbutazone, chloramphenicol, melphalan, Central phosphate amine, bimolane such as chemical drugs.

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5. Background The standard treatment for patients with multiple myeloma who are not candidates for high-dose therapy is melphalan and prednisone.

6. Adverse events were consistent with established profiles of toxic events associated with bortezomib and melphalan– prednisone .

7. Growing awareness of the similarities between "primary" amyloidosis and that associated with myelomatosis led to the trial of cytotoxic drug such as melphalan in the former condition(19)(20).

8. IT needs further clinical study to approve whether pulse oral melphalan can be a alternate to intravenous agent.

9. Methods Retrospective analysis for autologous transplant mainly with intravenous melphalan in 43 children with advanced malignant solid tumours was performed in our center.

10. Objective:To understand the efficiency of iso lated liver perfusion with melphalan for unresectable malignant liver tumors.