1. For melanoma, it has been shown that the de novo expression of ICAM-1 correlates with an increased risk of metastasis.

2. And such an inhibition might necessitate de novo protein synthesis.

3. Palmitoleate is involved in a process known as de novo lipogenesis, the production of fat molecules by fat cells.

4. The experiments showed that KT promoted SOD de novo biosynthesis mainly on the transciriptional level.

5. The de novo synthesis of PC increases in PE - SWD.

6. The experience of partial gastrectomy indicates that the time required for de novo growth of gastric carcinoma is about 15 years.

7. These results indicate that the second hepatocellular carcinoma was of independent clonality and probably represents a de novo neoplasm rather than a recurrence.

8. Adenylosuccinate lyase ( ADSL ) is a bifunctional enzyme catalyzing de novo purine synthesis and purine nucleotide recycling.

9. Conclusion The mutation, G 2043 R is cause of patient with DEB . It is a mutation of de novo.