1. There is a rare condition known as hereditary spherocytosis.

2. Objective To explore the feasibility and the efficacy of laparoscopic splenectomy of massive splenomegaly in the treatment of hereditary spherocytosis in children.

3. In benign group, postoperative hematologic parameters improved in cases of hereditary spherocytosis, idiopathic thrombocytopenic purpura and autoimmune hemolytic anaemia in proper order.

4. The sinusoids are packed with RBC's in this case of hereditary spherocytosis. The osmotic fragility of spherocytes is increased, because the RBC's have decreased surface area per unit volume.

5. Objective To analyze the causes of misdiagnosis and missed diagnosis in hereditary spherocytosis(HS) and improve the diagnosis rate.

6. Objective To analyze the clinical feature of children hereditary spherocytosis (HS).