1. Both aldosterone, a mineralocorticoid, and cortisol, a glucocorticoid, are inadequately secreted in this disorder.

2. Mineralocorticoid receptor antagonist: An MRA can provide significant antihypertensive benefit when added to existing multi - drug regimens.

3. Apparent mineralocorticoid excess is an autosomal recessive cause of hypertension and hypokalaemia which responds to glucocorticoid treatment.

4. The C2561T polymorphism of mineralocorticoid receptor gene is not exist in the Chinese population.

5. Conclusions1. Mineralocorticoid inhibition can prevent chronic renal interstitial fibrosis caused by AA.

6. Many of the states of increased urinary losses involve excessive mineralocorticoid effect.

7. Hypokalemia and metabolic alkalosis occur together in states of mineralocorticoid excess, with diuretic therapy or abuse, and in vomiting.

8. Objective: To study the changes of expression of glucocorticoid receptor(MR)and mineralocorticoid receptor(GR)in the paraventricular nucleus of the hypothalamus after adrenalectomy.