1 Objective To explore the clinical effectiveness of hemispherectomy on intractable epilepsy.

2 Objective To explore the effectiveness of modified hemispherectomy for intractable epilepsy in patients with infantile hemiplegia.

3 Most Johns Hopkins hemispherectomy patients are older than five years.

4 The investigators note that hemispherectomy has long been established for pediatric patients, but only a few case reports in adults have been published.

5 Objective To assess motor function of the extremities before hemispherectomy by transcranial magnetic stimulation motor evoked potential (TMS-MEP).

6 Objective To explore the character of clinic, EEG , histology and neuroradiology on hemimegalencephaly with intractable epilepsy, and to value the effect of hemispherectomy for hemimegalencephaly.