1. Where appropriate the absence of pyrogens should be monitored.

2. The main source of pyrogens is endotoxin.

3. It is very important to remove pyrogens from the intravenous injections of traditional Chinese medicines during preparing the intravenous injections.

4. Of this group of endogenous pyrogens(), most is known about interleukin-1(IL-1).

5. The FDA quickly gave permission to use this "Limulus amebocyte lysate, " or LAL, test for detecting pyrogens .

6. Casualties who received multiple transfusions over long periods of time tended to develop greater sensitivity to pyrogens.

7. The chief bottleneck in production was the elimination of pyrogens and testing for sterility.

8. AIM To establish an assay for the determination of bacterial endotoxins(BET) test of Cefotaxime sodium for injection to replace the test for pyrogens.

9. Objective : To establish a bacterial endotoxin test for monitoring pyrogens in compound lidocaine injection.

10. The Pyrogen test is a method to test the existence of pyrogens by using rabbits.

11. Results The quality standard of Chuankezhi injection was going to add the test for undue toxicity, pyrogens, hemolysis and cohesion, allergic reactions.

12. Conclusion:It is suitable for bacterial endotoxin test of Piperaillin Sodium and Piperacillin Sodium for Injection. And it may take place of test for pyrogens.