1. Concept: The fraction of unchanged drug reaching systemic circulation following administration by any route.

2. After a drug enters the systemic circulation , it is distributed to the body's tissues.

3. It is essentially a long, closed tube through which Blood moves in a double circuit-one through the lungs (pulmonary circulation) and one through the rest of the Body (systemic circulation).

4. Agriculture should participate in world market systemic circulation to must change backward face western.

5. As parietal cells release acid into the lumen of the stomach, they release bicarbonate into the systemic circulation.

6. If the hepatic capacity to eliminate portal endotoxins is exceeded, spillover into the systemic circulation will occur.

7. Its mechanism might be to improve the oxygen supply to hepatic tissues, enhance reticuloendothelial phagocytic function and reduce the concentration of NO and endotoxin in systemic circulation.

8. Process of drug movement from the administration site to the systemic circulation.

9. Bioavailability expresses the extent of drug absorption into the systemic circulation.

10. Conclusion Propofol can reduce the changes of HR, and protect the function of systemic circulation, pulmonary circulation and CI during acute myocardial ischemia-reperfusion injury in a canine model.

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11. Mucosal surfaces of recta are rich in blood supply, providing the means for rapid drug transport to the systemic circulation and avoiding, in most cases, degradation by first-pass hepatic metabolism.

12. It is directly proportional to the total amount of unchanged drug that reaches the systemic circulation.