1. There may be severe paresthesia.

2. Early symptoms: cold limbs, numbness, paresthesia, intermittent claudication etc.

3. BACKGROUND: Chronic pain, including hyperalgesia and algesthesia paresthesia, is pathological phenomenons making the patients felt unendurable and lacking of clinical treatments.

4. The major complications included paresthesia of the limbs , serum transaminase disorder and local skin necrosis.

5. There was no paresthesia, infection, or limitation of mouth opening after surgery.

6. Conclusion: Compared with paresthesia positioning method, PNS, using as nerve locator is more accurate in infraclavicular brachial plexus block with higher success rate.

7. Conclusion: There is no specific symptom for upper cervical spinal cord tumors, radicular pain and paresthesia or dysesthesia of limbs or trunk and muscle weakness are common manifestations.

8. The most commonly observed adverse events, all mild and transient, were headache, paresthesia, upper respiratory infection, dry mouth, nasopharyngitis , and constipation.

9. Proper distribution of action . Enzyme can cause burning , paresthesia, and dermatitis to surrounding skin.