1) The advantage of using oncolytic virus to treat pancre...

2) But the only "oncolytic virus" so far approved by a regulatory agency is for treatment of head and neck cancer in China.

3) Recently, the progress in cancer therapy for oncolytic viruses is very fast. Some oncolytic viruses have been used in clinical trials,(http:///oncolytic.html) which yield exciting results.

4) This new oncolytic adenovirus mutant has good clinical prospect in gene curing so to used in curing many kinds of human tumors.

5) In comparison, oncolytic viruses can replicate and spread and theoretically can efficiently reach more tumor cells.

6) Objective : To evaluate the selectively oncolytic effect of conditionally replicating adenovirus CNHK 500 in breast cancer.

7) The field of oncolytic viruses is a growing area in identifying new therapies for treating cancer.

8) Result: 5/35 chimeric oncolytic adenovirus possesses higher tumor-killing capacity to gastric cancer cells BGC-823 than type5 oncolytic adenovirus.

9) Objective To evaluate the effect of combined use of oncolytic virus and the chemotherapeutic agents mitomycin(MMC) in growth inhibition of human bladder cancer cell line T-24 in vitro.

10) Narrowing the treatment to a particular tumor cell type makes for a more effective and less harmful oncolytic approach.

11) This study is an important next step in advancing oncolytic virus therapies into cancer patients.

12) It is, therefore, feasible to exploit IL-8 promoter to control the replication of oncolytic adenovirus aiming to achieve more tumor-targeted oncolysis for treating NSCLC.

13) The study was to observe the induction of abscopal effect by the combination of H101 oncolytic virotherapy with local heating.

14) In this review, tumor targeting, killing efficiency, safety and the evaluation of oncolytic viruses therapy are discussed.

15) Methods: the authors use fluorescent microscope, flow cytometry and MTT assay to identify the tumor-killing capacity of 5/35 chimeric oncolytic adenovirus.

16) Information available at present suggests that Oncovin may be useful either alone or in conjunction with other oncolytic drugs for the treatment of acute leukaemias ......