1, Scientists call this claw shape the antibody molecule's idiotype.

2, In lymphoma, as cancerous B-cells develop and multiply unrestrained, each malignant B-cell expresses a unique idiotype or biomarker on the cell's surface, specific to each patient.

3, In order to reduce the human anti mouse antibody response and obtain optimal antigenicity, anti idiotype single chain which mimicking ovarian cancer antigen has been humanized.

4, The ex act mechanism was unknown, it related to the clonal deletion, clonal anergy, clonal ignorance, immune deviation, clonal abortion, receptor editing, anti- idiotype antibody and suppressor cells.

5, The strategy of tumor vaccine involves gene vaccine, peptide or protein vaccine, tumor cell vaccine modified by gene and anti idiotype antibody vaccine.

6, Peripheral blood Iymphocytes of patients with multiple myeloma were examined by using anti idiotype antibodies.

7, To explore the preparation of specific immune RNA on idiotype and further study immunotherapy of tumors.