1. Increasing evidence suggests that the thrombogenic tendency in atrial fibrillation is related to several underlying pathophysiological mechanisms.

2. Directly and indirectly thrombogenic components in plaque, together with blood , contribute to the thrombus formation.

3. OBJECTIVE:To promote the recovery of activity and thrombogenic safety of factor IX complex concentrate, and decrease the cost of the preparation.

4. Conclusion: The soft plaque with or without ulceration was considered more thrombogenic which can be displayed by ultrasound.

5. In addition, our data suggest that norpregnane derivatives may be thrombogenic, whereas micronized progesterone and pregnane derivatives appear safe with respect to thrombotic risk.

6. The existence of certain amount of low-molecular-weight heparin in ordinary heparin would increase the thrombogenic safety of the concentrate more greatly.

7. Conclusions - Key components of the molecular clock regulate the response to a thrombogenic stimulus in vivo.