1) Objective To perform early and presymptomatic diagnosis for facioscapulohumeral muscular dystrophy (FSHD).

2) Objective To study presymptomatic gene diagnosis in adult polycystic kidney disease (APKD).

3) Prenatal and presymptomatic diagnosis can be made in some family members by using these intragenic markers.

4) It was valuable for presymptomatic and antenatal diagnosis of NF1.

5) One crucial criterion in justifying a screening programme is that intervention is more effective in presymptomatic disease than after symptoms have appeared.

6) However, it is not easy to get a perfect presymptomatic marker of Parkinsons disease.

7) Mapping of the BRCT2 domain may aid in the presymptomatic risk assessment and provide a valuable tool for further study on the BRCT1 structure and function.

8) It is not clear whether the asymptomatic patients are presymptomatic cases that will eventually develop the syndrome, or whether they have a static condition.