1. The results showed that OA kneepad could delay cataplasia of articular cartilage by inhibiting cytokines and adjusting biological effect of MMP-3, HA.

2. Cataplasia: Degenerative reversion of cells or tissue to a less differentiated form.

3. Conclusions Lumbar dorsal muscle physiological cataplasia of female happened earlier than male, and intramuscular adipose degeneration happened earlier than muscle morphology atrophy.

4. As a result, the infernal circle finally lead to articular cartilage cataplasia.

5. Fusing in lower intervertebral of lumbar would evoke much more cataplasia in the adjacent segment.