1, Caffeine, phenobarbital, aminopyrine and phenacetin in antipyretic analgesic were determined using two-point internal standard method.

2, Piracetam tablets were determined by HPLC using phenacetin as internal standard.

3, The free and combined metabolites of phenacetin in plasma were assayed with HPLC.

4, It is often administered with aspirin, codeine, or phenacetin as an analgesic preparation.

5, The present paper described an application of activated carbon to the phenacetin production in details.

6, An recover technique of hyposulfite of the accessory substances of phenacetin through simplex method was studied.

7, Methods: BP network spectrophotometry was selected to determine aminopyrine and phenacetin in Qutongpian.

8, This method is used to determine the ternary mixture of aspirin, phenacetin and caffeine in APC simultaneous with satisfactory results.

9, CONCLUSION Liver cells were damaged severely in the rats with DEN induced hepatoma. The liver mass increased without any significant changes in the liver function tests as phenacetin metabolites.