1 OBJECTIVE:Improve the synthetic method of diphenoxylate hydrochloride, which was more suitable for the industrial process.

2 Objective:To understand the situation of compound diphenoxylate tablets abuse in Kunming.

3 A rapid method for the simultaneous determination of diphenoxylate and atropine by capillary electrophoresis with high frequency conductivity detection was described.

4 METHODS:Mouse model of constipation was established by compound diphenoxylate, and rat model hyperlipemia was established by high fat forage.

5 Methods It was taken orally with Asi antidiarrheal capsule in treatment group and taken orally with Diphenoxylate in control group.

6 HPLC method for the determination of atropine sulfate in compound diphenoxylate tablets was established.

7 A HPLC method for the determination of atropine sulfate in compound diphenoxylate tablets was established.

8 Adverse reaction of otilonium bromide was few, but colloidal bismuth and diphenoxylate can cause the constipation after using for a long time.

9 Method:32 cases were treated with Repleshing Spleen to Stop Diarrhea Decoction as the study group while 30 cases were treated with Vit B1, Compond Diphenoxylate and Berberine as the control group.