1, Objective:To establish the method for determination of Propylthiouracil Tablets.

2, Objective To study the clinic pathological characteristics of propylthiouracil(PTU)-induced antineutrophil cytoplasmic antibody(ANCA) positive small vessel vasculitis.

3, Methods Replicated the hypothyroid rat model with propylthiouracil (PTU), and then detected the positive cells of PCD in sections by TdT-mediated dUTP nick end labeling.

4, Of course, antithyroid drugs, such as propylthiouracil and tapazole are used to control the symptoms.

5, To clarify the onset, development, clinical manifestations and management of propylthiouracil(PTU)-induced granulocytopenia.

6, Results:On the basis of drug informatics, the adverse reactions of propylthiouracil were fully understood and efficiently used in clinical pharmacy practice.

7, Objective To study the changes of thyroid function of hyperthyroidism in pregnancies, and the effects on gestation and the fetus with propylthiouracil(PTU).

8, AIM: To study the pharmacokinetics and relative bioavailability of propylthiouracil tablet in Chinese healthy male volunteers.

9, Objective To study the clinical characteristics and factors of symptomatic propylthiouracil (PTU) -induced hepatic injury in patients with hyperthyroidism.