1. Sciele's spray-on drug contains lidocaine and prilocaine, which act on sensory nerve endings in the penis, said Dr. Mike Wiley, director of urology for Sciele.

2. A method for the simultaneous determination of prilocaine and lidocaine in vitro percutaneous absorption liquid using gas chromatography-mass spectrometry (GC-MS) has been developed.

3. The possibility of the eutectic mixture of lidocaine and other local anaesthetic drugs was investigated except for prilocaine.

4. IMPLICATIONS: Local anesthetic-related methemoglobinemia is a recurring problem and may lead to life-threatening events. The clinical use of benzocaine and prilocaine needs to be reassessed.

5. OBJECTIVE To develop a method for the measurement of lidocaine and prilocaine in compound cream.

6. These creams contain high doses of local anesthetics including lidocaine , tetracaine , benzocaine, and prilocaine.