1) Many nuclei have become pyknotic (shrunken and dark) and have then undergone karorrhexis (fragmentation) and karyolysis (dissolution). The cytoplasm and cell borders are not recognizable.

2) Many nuclei have become pyknotic (shrunken and dark) and have then undergone karorrhexis (fragmentation) and karyolysis (dissolution).

3) Many nuclei have become pyknotic and have then undergone karorrhexis and karyolysis.

4) Notice how flat the surface cells are and how dark and pyknotic their nuclei have become.

5) RESULTS: The layer of CA1 pyramidal cells in both AO groups became thinner with pyknotic nuclei than control.

6) The cytologic features of normal squamous epithelial cells can be seen at the center top and bottom, with orange to pale blue plate-like squamous cells that have small pyknotic nuclei.

7) Vacuole degeneration was found in epithelium cells and brush border of lumen surface fell off and reduced with pyknotic nucleus in proximal convoluted tubules of arsenism rats.